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Mitral valve repair and mitral valve replacement are procedures that may be performed to treat diseases of the mitral valve — the valve located between the left heart chambers (left atrium and left ventricle). Treatment for mitral valve disease depends on the severity of your condition. May recommend surgery to repair or replace mitral valves for some people with mitral valve disease. Several surgical procedures exist to repair or replace mitral valves, including open-heart surgery or minimally invasive heart surgery.